低氘氫水實驗室

 Retinal ischemia-reperfusion (I/R) injury by transient elevation of intraocular pressure (IOP) is known to induce neuronal damage through the generation of reactive oxygen species. Previous studies indicate that molecular hydrogen (H2) is an efficient antioxidant gas that selectively reduces the hydroxyl radical (•OH) and suppresses oxidative stress-induced injury in several organs. This study was conducted to explore the neuroprotective effect of H2-loaded eye drops on retinal I/R injury.

從07年到現在，日本學者共發表相關文章12篇，其中日本醫科大學的太田成男教授有11篇。幾乎佔這個領域的總數量的1半，仍是這個領域的第一。美國有三個大學開始這方面的研究，目前進展儘管比較快，但仍與日本的有一些差距。日本學者主要的方向是，腦、肝和心方面。美國的主要是小腸和肝。我們只在肺損傷方面有一些新意，其他在器官方面沒有突出表現。唯一值得炫耀的是製備了含氫生理鹽水，但並不是特別的創新。本文是除我們以外採用含氫生理鹽水唯一的一篇論文。日本學者無論如何，每次都引用我們的文章，從這個方面看，太田成男教授對我們的研究是比較認可的。到目前，我們的第一篇這方面的文章引用次數已經超過10次（發表了1年），第二篇2009年發表的論文引用也已經達到8次。

這是採用局部用藥的方法，證明氫氣能治療視網膜缺血再灌注損傷。特別指出，這個文獻是作者直接發給我的。沒有經過檢索。特此謝謝。

這也說明他們一直在這方面開展一些工作，我們不能放鬆。

關於這個研究，實際上我們也開始，但採用的研究手段是不同的，研究結果也不如他們的理想。科研工作就是這樣，儘管你能想到，甚至做到，但是如果晚了，就幾乎是完了。

Abstract

PURPOSE. 

METHODS. 

Retinal ischemia was induced in rats by raising IOP for 60 minutes. H2-loaded eye drops were prepared by dissolving H2 gas into a saline to saturated level and administered to the ocular surface continuously during the ischemia and/or reperfusion periods. One day after I/R injury, apoptotic cells in the retina were quantified and oxidative stress was evaluated by markers such as 4-hydroxynonenal and 8-hydroxy-2-deoxyguanosine. Seven days after I/R injury, retinal damage was quantified by measuring the thickness of the retina. RESULTS.When H2-loaded eye drops were continuously administered, H2 concentration in the vitreous body immediately increased and I/R-induced •OH level decreased. The drops reduced the number of retinal apoptotic and oxidative stress marker-positive cells , and prevented retinal thinning with an accompanying activation of Müller glia, astrocytes, and microglia. The drops improved the recovery of retinal thickness by >70%. CONCLUSIONS. H2 has no known toxic effects on the human body. Thus, our study suggests that H2-loaded eye drops will be a highly useful neuroprotective and anti-oxidative therapeutic treatment for acute retinal I/R in

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