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氫分子醫學的新啟示:一些臨床藥物的奇怪作用

 

這個觀點實際上與我去年的文章是類似的,我們去年提出的觀點是內源性氫是一種抗氧化物質,這個文章的觀點是有些糖尿病藥物,可抑制能量物質吸收,有一個明顯的副作用是大腸內產生氣體,這類藥物往往具有器官保護作用。過去一直不明白為什麼這樣。日本學者提出的這個觀點,我是非常同意。過去1年我們課題組多次討論到這個話題。可惜我們沒有把這個觀點形成文章。真的十分可惜。

Hypothesis

Are the effects of 

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Yoshihiko Suzuki a, Motoaki Sano cCorresponding Author Contact InformationE-mail The Corresponding Author, Kentaro Hayashida c, Ikuroh Ohsawa ab, Shigeo Ohtaaand Keiichi Fukudac

Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

The Center of Molecular Hydrogen Medicine, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160-8582, Japan

Received 20 April 2009; 
revised 28 May 2009; 
accepted 31 May 2009. 
Available online 8 June 2009. 

α -glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

Abstract

The major side-effect of treatment with α -glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of α -glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H 2in the gastrointestinal tract. Acarbose, which is an α -glucosidase inhibitor, markedly increased H 2production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H 2acts as a unique antioxidant, and that when inhaled or taken orally as H 2-dissolved water it ameliorates ischaemia–reperfusion injury and atherosclerosis development.

Keywords: α -Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant

Article Outline

1. Introduction
2. Molecular hydrogen (H 2) acts as a novel antioxidant
3. Unexpected benefit of flatulence caused by α -glucosidase inhibitors
4. Conclusion
Conflict of interest statement
Acknowledgements
References

Corresponding Author Contact InformationCorresponding author. Address: Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Fax: +81 3 5363 3875.

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