氫水還原健康–氫氣對巴金森氏病的治療和預防作用

 

  今天檢索發現.

本研究利用腦內註射6-hydroxydopamine製備動物模型, 通過飲用含氫生理鹽水的方法,觀察形態學和行為學改變,證明氫氣可以治療該疾病.這是氫氣分子醫學的又一進展,目前已經有9種疾病被證明有效.

到目前已經有14篇有關研究論文.其中日本有9篇,進展非常快

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease

 

Yuan Fu , Mikako Ito , Yasunori Fujita , Masafumi Ito , Masatoshi Ichihara , Akio Masuda , Yumi Suzuki , Satoshi Maesawa , Yasukazu Kajita , Masaaki Hirayama , Ikuroh Ohsawa , Shigeo Ohta and Kinji Ohno a

 

 

Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Kakamigahara 504-0838, Japan

Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-8501, Japan

Department of Neurosurgery, Nagoya Central Hospital, Nagoya 453-0801, Japan

Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 211-8533, Japan

Received 17 November 2008; 

revised 23 January 2009; 
accepted 7 February 2009. 
Available online 12 February 2009. 

 

 

 

 

Abstract

Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen has been reported to prevent or ameliorate eight diseases in rodents and one in human associated with oxidative stress. In Parkinson’s disease, mitochondrial dysfunction and the associated oxidative stress are major causes of dopaminergic cell loss in the substantia nigra. We examined effects of 50%-saturated molecular hydrogen in drinking water before or after the stereotactic surgery on 6-hydroxydopamine-induced nigrostrital degeneration in a rat model of Parkinson’s disease. Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. Tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson’s disease.

Keywords: Parkinson’s disease; Molecular hydrogen; Oxidative stress

 

 

 

 


 

  

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