氫水還原健康-氫氣治療維生素C缺乏引起的神經損傷

 

這個研究採用基因缺陷動物模型,對這個模型不太熟悉。有研究發現這種動物在維生素C缺乏時,腦內超氧離子水平升高。看來是一個腦氧化損傷的模型。這個文章也有體外腦片的內容。不過好像不是直接效應,而是用了氫後造成的後續影響。因此說可影響超氧陰離子的說法不准確。最近我們在投稿時,有人根據這個文獻給我們提出:選擇性抗氧化的作用不能明確。有一些強詞奪理。

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice
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Yasunori Sato 1, Shizuo Kajiyama 1, Akiko Amano , Yoshitaka Kondo , Toru Sasaki , Setsuko Handa , Ryoya Takahashi , Michiaki Fukui , Goji Hasegawa , Naoto Nakamura , Hikohito Fujinawa , Toyotaka Mori , Mitsuhiro Ohta , Hiroshi Obayashi , Naoki Maruyama and Akihito Ishigami b

 

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University, Chiba 274-8510, Japan

Aging Regulation, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan

Kajiyama Clinic, Kyoto 615-0035, Japan

Research Team for Molecular Biomarker, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

I’rom Pharmaceutical Co., LTD., Tokyo 141-0032, Japan

Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe 658-8566, Japan

Institute of Bio-Response Informatics, Kyoto 612-8016, Japan

 

Received 31 July 2008.

Available online 14 August 2008.

 

 

Abstract

Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen’s effect in the brain, we administered hydrogen-rich pure water (H 2) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout ( KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant. These KO mice were divided into three groups; recipients of H 2, VC, or pure water (H2O), administered for 33 days. VC levels in H 2and H 2O groups were <6% of those in the VC group. Subsequently, superoxide formation during hypoxia-reoxygenation treatment of brain slices from these groups was estimated by a real-time biography imaging system, which models living brain tissues , with Lucigenin used as chemiluminescence probe for superoxide. A significant 27.2% less superoxide formed in the H 2group subjected to ischemia–reperfusion than in the H 2O group. Thus hydrogen-rich pure water acts as an anti-oxidant in the brain slices and prevents superoxide formation.

 

 

Keywords: Ascorbic acid; Chemiluminescence; Gluconolactonase; Hydrogen-rich pure water; Oxidative stress; ROS; Senescence marker protein-30; Superoxide; Vitamin C

 

 

Abbreviations: EDTA, ethylenediaminetetraacetic acid; GNL, gluconolactonase; HPLC, high-performance liquid chromatography; KO, knockout; ROS, reactive oxygen species; SMP30, senescence marker protein-30; SOD, superoxide dismutase; VC, vitamin C

 

Article Outline

 

Materials and methods
Results
Effect of hydrogen-rich pure water on body weight
Total vitamin C levels in the brain after ingestion of hydrogen-rich pure water
Superoxide formation during hypoxia-reoxygenation in a model of the living brain
Discussion
Acknowledgements
References

 

全文

 

 

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