低氘氫水實驗室 研究項目

  1. 極超高純氫氣研究—7N、8N維米製程氫氣
  2. 固態儲氫器研究、太空船用固態儲氫器研究
  3. 低氘飽和氫水製程研究及應用研究
  4. 低氘水用於生物實驗及製藥應用研究
  5. 氫氣呼吸之劑量及物理效應研究
  6. 低氘水用於育苗育種農業生技研究
  7. 氫氣用於食品科學研究
  8. 低氘水用於食品科學研究
  9. 呼吸氫氣及低氘飽和氫水之於癌症、中風、巴金森症、妥瑞症、糖尿病、心肌損傷、肝損傷、腦中風、放射治療損傷、老年癡呆、心肌硬塞、痛風、COPD、異位性皮膚炎、僵直性脊椎炎、過敏、紅斑性狼瘡及自體免疫性疾病之觀察研究

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氫水還原健康–長期飲用氫水可保護心臟和大血管移植後損傷

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該摘要沒有正式發表,但是研究內容比較好,放在這裡供大家學習參考。根據這個研究思路,對肝臟、腎臟和皮膚等器官移植的研究可提供比較好的借鑒作用。

 

Adding a Hydrogen-producing Magnesium stick to the drinking water protects cardiac allografts and reduces allograft vasculopathy in rats

Atsunori Nakao, Sungsoo Lee, Chien-sheng Huang, Zhiliang Wang,

Norihisa Shigemura, Yoshiya Toyoda

Background

Oxidative stress likely contributes to allograft vasculopathy and interstitial fibrosis, limiting long-term survival after cardiac transplantation. Molecular hydrogen (H 2) has therapeutic value as an antioxidant through its ability to selectively reduce cytotoxic reactive oxygen species. We hypothesized that drinking hydrogen water (HW ) would protect cardiac and aortic allograft recipients from allograft vasculopathy via the antioxidant and anti-inflammatory effects of H 2. We further tested whether therapeutic HW could be generated via a magnesium (Mg) stick placed in the drinking water.

Methods

Allogeneic heterotopic heart transplantation (HTx) and aortic transplantation were performed in rats (LEW and BN) with tacrolimus immunosuppression (0.5 mg/kg, days 0-6). HW was generated either by bubbling hydrogen gas through tap water or with a Mg stick immersed in tap water (Mg + 2H 2O → Mg (OH) 2+ H 2). For 100 continuous days, beginning the day of transplantation, recipients were given either regular water (RW), HW, or HW that had been subsequently degassed. Graft survival was assessed by daily palpation for a heartbeat. Aortic grafts were harvested at day 60 for histologic analysis.

Results

Oral administration of HW generated with a Mg stick (H 2concentration: 0.6 mM) caused a significant elevation in blood H 2(up to 28.6 ± 2.9 µM 15 min after intake) as compared to RW (8.1 ± 0.4 µM). Supplementation of H inthe drinking water , either by reaction with the Mg stick or by bubbling with H 2gas ( 0.5 mM), was remarkably effective in prolonging heart graft survival (median of >100 days for both) without adverse effects. In contrast, heart grafts survived 49.5 days in animals given RW and 51.5 days in animals given degassed HW.   At day 50, there was a marked increase in graft infiltrating cells, including macrophages and T cells.   HW reduced inflammatory cell infiltration and graft lipid peroxidation.   Drinking HW also reduced intragraft mRNA levels for IFNγ at day 50.  While Verhoeff’s van Gieson staining of transplanted aortas showed massive neointimal hyperplasia associated with the accumulation of αSMA-positive smooth muscle cells, HW treatment significantly reduced these pathological changes in aortic allografts.

Conclusion

Dissolving H 2 indrinking water prolongs survival of cardiac allografts. Drinking HW may protect cardiac allografts from allograft vasculopathy. The HW-producing Mg stick may have novel therapeutic value in HTx due to its portability.

 

 


 

  

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低氘氫水實驗室

低氘氫水實驗室

TEL:0963-788-693
email: ddh2water@gmail.com
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