氫氣對新生兒窒息後腦損傷有保護作用

學者孫學軍 發表於2010-7-27 11:05:30

 

氫氣對新生兒窒息後腦損傷有保護作用

兩年前,我們課題組曾經報導,呼吸氫氣對新生兒缺血缺氧腦損傷具有保護作用,本研究是採用豬為模型,用停止呼吸來模擬窒息,更符合臨床新生兒窒息的實際,結果發現呼吸氫氣對窒息引起的神經損傷有明確的保護作用,而且對窒息後腦網膜血管二氧化碳反應性有明顯增加效應,提示對血管損傷也有很好的保護作用。從作者單位是匈牙利Department of Physiology [F.D., O.O., A.Z., V.T., M.H.], Department of Dermatology and Allergology [I.N.], Department of Medical Informatics [F.B.] University of Szeged School of Medicine, Szeged, H-6720, Hungary; Department of Pediatrics [P.T.], University Teaching Hospital Orosháza, Orosháza, H-5900, Hungary.這是自日本、中國和美國之後,另外增加了一個國家參與氫氣生物學效應研究的國家:匈牙利

論文摘要,氫氣能中和毒性活性氧,氧化應激是新生兒窒息後神經損傷的重要機制。本研究讓動物呼吸含2.1%氫氣的空氣,結果發現能有效保護窒息引起的腦血管反應性和腦組織病理改變。動物分成2組,呼吸空氣組和空氣含氫氣組,並分別分成不同的時間組。窒息方法是停止呼吸10分鐘,然後通氣4小時。復蘇後,腦組織進行形態學觀察。腦膜血管直徑通過在體血管反應性檢測,動物呼吸5-10%二氧化碳和10-4M NMDA,採用顱骨開窗,顯微鏡檢測窒息前和窒息後1小時對比血管直徑。病理學檢測結果發現,呼吸氫氣能對所有檢測部位:如大腦皮層、海馬、基底核、小腦和腦幹窒息引起的神經損傷均有明顯的治療作用。而且呼吸氫氣能有效保護窒息引起的腦血管反應性降低(二氧化碳呼吸,但對NMDA誘導效應無作用)。研究結果提示,呼吸氫氣對新生兒窒息後神經損傷具有非常理想的保護作用。

 

Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs全文

Domoki, Ferenc; Oláh, Orsolya; Zimmermann, Aliz; Németh, István; Tóth-Szuki, Valéria; Hugyecz, Marietta; Temesvári, Péter; Bari , Ferenc

Department of Physiology [F.D., O.O., A.Z., V.T., M.H.], Department of Dermatology and Allergology [I.N.], Department of Medical Informatics [F.B.] University of Szeged School of Medicine, Szeged, H-6720, Hungary; Department of Pediatrics [P.T.], University Teaching Hospital Orosháza, Orosháza, H-5900, Hungary.

 

 

Abstract

Hydrogen (H2) has been reported to neutralize toxic reactive oxygen species (ROS). Oxidative stress is an important mechanism of neuronal damage after perinatal asphyxia. We examined if 2.1% H2-supplemented room air (H2-RA) ventilation would preserve cerebrovascular reactivity (CR) and brain morphology after asphyxia/reventilation (A/R) in newborn pigs. Anesthetized, ventilated piglets were assigned to one of the following groups: A/R with RA or H2-RA ventilation (A/R-RA and A/R-H2-RA; n=8,7), and respective time control groups (n=9,7). Asphyxia was induced by suspending ventilation for 10 min, followed by reventilation with the respective gases for 4 hours. After euthanasia, the brains were processed for neuropathological examination. Pial arteriolar diameter changes to graded hypercapnia [5-10%CO2 inhalation] and NMDA, [10-4M]) were determined using the closed cranial window/intravital microscopy before and 1h after asphyxia. Neuropathology revealed that H2-RA ventilation significantly reduced neuronal injury induced by A/R in virtually all examined brain regions including the cerebral cortex, the hippocampus, basal ganglia, cerebellum, and the brainstem. Furthermore, H2-RA ventilation significantly increased CR to hypercapnia after A/R (% vasodilation was 23+/-4% versus 41+/-9%*, *p<0.05). H2-RA ventilation did not affect ROS-dependent CR to NMDA. In summary, H2-RA could be a promising approach to reduce the neurological deficits after perinatal asphyxia.

(C) International Pediatrics Research Foundation, Inc. 2010. All Rights Reserved.

 

Published Ahead-of-Print

 

本文引用地址: http://www.sciencenet.cn/m/user_content.aspx?id=347672

* 本文僅代表博主個人觀點,與科學網無關。

 

 

當前推薦數:6    推薦人: xupeiyang zhangling zhengyongjun baoyu qlms gaojianguo  

[4] 標題:

發表評論人:[遊客]youke [2010-7-27 18:51:28] ip:61.152.251.*  

用猴子實驗最好了

 

[3] 標題:

發表評論人:zhengyongjun [2010-7-27 13:03:14]   

拜讀
博主回復:謝謝

 

[2] 標題:

發表評論人:[遊客]pp [2010-7-27 12:42:03] ip:61.152.251.*  

用豬實驗的比較少

 

[1] 標題:

發表評論人:zhangling [2010-7-27 12:40:32]   

mice rat pig monkey human being. I am looking forward to reading the more progress in hydrogen medicine.

 

 

 

 

 


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