1.2.1 ２型糖尿病に対する臨床試験
Nutrition Research
学術雑誌名：
Nutrition Research,28（2008）p137～143
表題：Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance （ 水素豊富水投与により、２型糖尿病患者の脂質、糖代謝の改善、または耐糖能が改善）
概要：純水に水素ガスを加えて作成した水素豊富水を、毎日900ｍｌ 8週間摂取させて、 ２型糖尿病に対する効果を、プラセボ群と比較した。
水素水群において、抗酸化作用（イソプラスタンの低下、抗酸化酵素の上昇）、 抗動脈硬化作用、血糖値の低下、耐糖能の改善等２型糖尿病予防に有用な効果が認められた。
營養研究
學術期刊名稱：
營養學研究，28（2008）P137〜143
標題： 氫水補充葡萄糖和脂質代謝改善糖尿病患者或糖耐量異常型兩種（氫水對血脂患者2型糖尿病，改善糖代謝，或改善糖耐量）
摘要： 每天攝取900毫升8週，對2型糖尿病，與安慰劑組。
抗氧化（減少 isoprostane，增加抗氧化酶），抗動脈粥樣硬化的作用，降低血糖水平，顯示效果有利於預防 2型糖尿病和改善糖耐量。
<孫醫師部落格>
這是目前唯一的人類為研究對象的論文。研究的方法比較簡單，嚴格講，不能算糖尿病，只是高血糖患者。飲用含氫水8週，2月後。發現患者的血糖有明顯降低，胰島素有一定升高。很奇怪。 Oxidative stress is recognized widely as being associated with various disorders including
diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a reducing action.
We therefore investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism
in patients with either type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We
performed a randomized, double-blind, placebo-controlled, crossover study in 30 patients with
T2DM controlled by diet and exercise therapy and 6 patients with IGT. The patients consumed either
900 m L/d of hydrogen-rich pure water or 900 mL of placebo pure water for 8 weeks, with a 12-week
washout period. Several biomarkers of oxidative stress, insulin resistance, and glucose metabolism,
assessed by an oral glucose tolerance test , were evaluated at baseline and at 8 weeks. Intake of
hydrogen-rich water was associated with significant decreases in the levels of modified low-density
lipoprotein (LDL) cholesterol (ie, modifications that increase the net negative charge of LDL), small
dense LDL, and urinary 8-isoprostanes by 15.5% (P b .01), 5.7% (P b .05), and 6.6% (P b .05),
respectively. Hydrogen-rich water intake was also associated with a trend of decreased serum
concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and
extracellular-superoxide dismutase. In 4 of 6 patients with IGT, intake of hydrogen-rich water
normalized the oral glucose tolerance test. In conclusion, these results suggest that supplementation
with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance.
© 2008 Elsevier Inc. All rights reserved.全文
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