氫氣水對移植心臟炎症損傷的保護作用

 氫氣水對移植心臟炎症損傷的保護作用

已有1187次閱讀 2012-8-18 01:03 個人分類飲用氫氣水 | 系統分類: 科研筆記 | 關鍵詞:氫氣炎症office

文章來自美國匹茲堡大學,發表在《移植國際》雜誌 ​​上。美國匹茲堡大學Nakao課題組主要致力於氫氣對器官移植損傷保護作用的研究,先後發表氫氣對小腸、心臟、肺、腎臟、血管等器官移植後損傷方面的高水平研究論文。上周剛發表在肺組織移植和基因表達相互關係的研究。這週又發表氫氣水對心臟移植保護作用的研究。

文章中使用的氫氣水有兩種,一是用金屬鎂和水反應產生,另一種是用氫氣在水中充氣泡產生,

充氣泡產生氫氣溶液是氣體溶液研究中最經典傳統的手段,過去氫氣生物學領域一直認為,這樣的方法可能不能製備出符合濃度要求的氫氣溶液,但最近有一些研究先後發現,這樣的土方法,仍可以製備出具有治療作用的氫氣溶液,這也給普通學者甚至普通的消費者提供了一種製備氫氣水的“技術”,就是簡單地把氫氣用管子通入水中吹泡,大概10分鐘,就可以製備出一瓶可以對身體有好處的保健水。氫氣的製備非常容易,或者可以直接購買氫氣發生器使用。當然作為研究手段,這樣的方法仍有不准確的嫌疑。不過這也給過去許多氫氣的研究提出一種潛在的挑戰:氫氣的有效濃度或有效劑量到底有多低?

考慮到許多氫氣電極的校對方式為這種充氣法,但這樣的溶液可能沒有達到真正的飽和溶液,這樣的標準溶液就非常容易產生誤差,導致檢測的數據偏大。也許過去許多研究中所聲稱的氫氣濃度,甚至在體檢測的氫氣濃度都存在比較大的水分。

該研究在證明氫氣效應後,重點從組織的炎症因子,白細胞介素2gama干擾素角度觀察氫氣對抗炎症的作用,促進線粒體氧化磷酸化代謝相關的酶,提高組織細胞ATP水平,說明氫氣不僅具有抗炎症的作用,而且具有提高組織能量代謝的能力。體外實驗證明氫氣可以減少T細胞的增殖。關於T細胞增殖體外研究,在2009年哈佛大學關於大腸細菌產生氫氣治療肝炎的論文也曾經使用過。當然,兩個研究希望說明的問題是不同的,因此儘管是重複,仍具有價值,這就是生物學研究。

 

 

 


 

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Transpl Int. 2012 Aug 14. doi: 10.1111/j.1432-2277.2012.01542.x. [Epub ahead of print]

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration.

Noda K , Tanaka Y , Shigemura N , Kawamura T , Wang Y , Masutani K , Sun X , Toyoda Y ,Bermudez CA , Nakao A .

Source

Department of Cardiothoracic Surgery, Pittsburgh, PA, USA Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan.

Abstract

Recent evidence suggests that molecular hydrogen has therapeutic value for disease states that involve inflammation. We hypothesized that drinking hydrogen-rich water (HW) daily would protect cardiac and aortic allograft recipients from inflammation-associated deterioration. Heterotopic heart transplantation with short-course tacrolimus immunosuppression and orthotopic aortic transplantation were performed in allogeneic rat strains. HW was generated either by bubbling hydrogen gas through tap water (Bu-HW) or via chemical reaction using a magnesium stick [Mg + 2H(2) O Mg (OH)(2 ) + H(2) ] immersed in tap water (Mg-HW). Recipients were given either regular water (RW), Mg-HW, Bu-HW, or Mg-HW that had been subsequently degassed (DW). Graft survival was assessed by daily palpation for a heartbeat. Drinking Mg-HW or Bu-HW was remarkably effective in prolonging heart graft survival and reducing intimal hyperplasia in transplanted aortas as compared with grafts treated with RW or DW. Furthermore, T cell proliferation was significantly inhibited in the presence of hydrogen in vitro, accompanied by less production of interleukin-2 and interferon-γ. Hydrogen treatment was also associated with increased graft ATP levels and increased activity of the enzymes in mitochondrial respiratory chain. Drinking HW prolongs survival of cardiac allografts and reduces intimal hyperplasia of aortic allografts.

© 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation.

 

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