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Cardinal and colleagues describe the use of molecular hydrogen, the most abundant molecule in the universe, as a treatment for chronic allograft nephropathy (CAN) in a rat model of kidney transplantation. They demonstrate that the addition of hydrogen to the drinking water results in a decrease in the severity of CAN and increased graft survival, and they provide evidence that the mechanism of action could be due to a reduction in reactive oxygen species. Kidney International (2010) 77, 85–87. doi:10.1038/ki.2009.432
圖中的觀點需要商榷，氫氣目前不能證明能中和超氧自由基。
Given
previous data, the interpretation that the
benefi cial eff ects of H 2 in a kidney transplant
model are a result of antioxidant
properties of the element is reasonable
and likely. However, this may not be the
sole explanation, and other as-yet undefi
ned mechanisms may be involved. Th e
presence of basal levels of H 2 indicates one
or more endogenous sources, suggesting
that it plays a physiological role. Precedent
for this possibility can be easily found in
other gas-generating systems.
Therefore, given the
increasing number of systems in which H 2
is being shown to mediate beneficial
eff ects, and likely, in the future, deleterious
ones as well, it is probable that involvement
of H 2 in signaling pathways or other
physiological functions will be found.
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