這個沒有摘要和全文,只有題目. 有具體內容後再修改. 這說明有人在進行這方面的探討.值得注意
Copyright © 2009 International Society for Heart and Lung Transplantation Published by Elsevier Inc.
135: Combined Administration of Gas and Carbon Monoxide Is a Superior Strategy for Ameliorating Cardiac Cold Ischemia/Reperfusion Injury in Rats Hydrogen
a Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, PA
COMBINED ADMINISTRATION OF HYDROGEN AND CARBON MONOXIDE IS ASUPERIORSTRATEGY FOR AMELIORATIONG CARDIAC COLD ISCHEMIA/REPERFUSION INJURY
Atsunori Nakao, David J Kaczorowski, Ryujiro Sugimoto, Jianghua Zhan, Yinna Wang, Kenneth R McCurry
Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh
Department of Surgery, University of Pittsburgh
Background : Hydroxyl radicals, generated during ischemia/reperfusion injury (IRI), play a critical role in graft injury. Recently, it has been reported that hydrogen (H 2) gas alleviates oxidative injury by selectively neutralizing hydroxyl radicals. In this study, we evaluated the combined effects of H 2 with carbon monoxide (CO), a molecule known to have anti-inflammatory and anti-apoptotic properties.
Methods : Syngeneic, heterotopic HTx (LEW rats) was performed with 18 hrs of cold ischemia time. In the H 2or CO treated group, both donor and recipients were treated with H 2(2%) or CO (250 ppm) in air 1 hr before and 1 hr after reperfusion.
Results : In control (air) recipients, serum troponin I (TnI) and CPK levels increased within 3 hrs, but were significantly attenuated with H 2treatment. Cardiomyocyte apoptosis, prevalent in control grafts at 6 hrs, was also significantly attenuated with H 2. H 2treatment resulted in significantly reduced MDA levels after transplant, demonstrating attenuated lipid peroxidation, and also reduced serum high-mobility group box-1 (HMGB1) levels. CO had marginal effects on preventing lipid peroxidation and myocardial oxidative injury. However, CO suppressed inflammatory responses, reducing graft mRNA levels for TNFα and serum IL-6, whereas H 2did not. These results suggest that H 2does not possess direct anti-inflammatory effects, but CO does. Conversely, while H 2has potent anti-oxidant properties, CO has marginal effects in scavenging radicals. Dual therapy with CO and H2demonstrated both anti-oxidant and anti-inflammatory effects.
Conclusion : Mixed gas therapy with CO and H 2is a novel, safe and potent approach for preventing cardiac cold IRI.
Table. The effects of CO and hydrogen for cardiac cold I/R injury (*p<0.05 vs HTx/air)
|
|
TnI (3h) |
CPK (IU/L, 3h) |
TUNEL (6h) |
MDA (3h) |
HMGB1 (1h) |
Serum IL-6 (3h) |
|
normal |
1.1 |
101 |
7.4 |
0.47 |
0.08 |
21 |
|
HTx (air) |
224.7 |
15312 |
55.4 |
0.85 |
4.3 |
928.1 |
|
HTx (CO) |
160.3 |
9171 |
35.2 |
0.83 |
3.8 |
462* |
|
HTx (H 2) |
80.5* |
5458* |
24.3* |
0.65* |
2.6 |
872.1 |
|
HTx (CO/H 2) |
47.5* |
4405* |
22.1* |
0.59* |
2.7 |
206.4* |
具體內容可以參考其一綜述:
J Clin Biochem Nutr.
Nakao A , Sugimoto R , Billiar TR , McCurry KR.
Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Medical gases are pharmaceutical gaseous molecules which offer solutions to medical needs and include traditional gases, such as oxygen and nitrous oxide, as well as gases with recently discovered roles as biological messenger molecules, such as carbon monoxide, nitric oxide and hydrogen sulphide. Medical gas therapy is a relatively unexplored field of medicine; however, a recent increasing in the number of publications on medical gas therapies clearly indicate that there are significant opportunities for use of gases as therapeutic tools for a variety of disease conditions. In this article, we review the recent advances in research on medical gases with antioxidant properties and discuss their clinical applications and therapeutic properties.
PMID: 19177183 [PubMed – in process]
PMCID: PMC2613492
Available online 24 January 2009.
A. Nakao * , a , DJ Kaczorowski a , R. Sugimoto a , J. Zhan a , Y. Wang a and KR McCurry a
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