高壓氫氣治療肝寄生蟲的研究

法國潛水醫學領域繼續針對高壓氫的抗氧化作用進行研究,採用8個大氣壓的氫治療肝寄生蟲曼森血吸蟲感染感染引起的肝炎症損傷,仍從抗氧化的角度去分析,研究表明呼吸一定時間的氫具有抗炎症作用.

到這個時期, 人們考慮到氫的溶解度低,抗氧化需要比較高的分壓. 思路上沒有什麼問題. 而且沒有從選擇性上考慮問題是非常遺憾的.

Anti-inflammatory properties of molecular
hydrogen: investigation on parasite-induced liver
inflammation
Bouchra Ghariba, Stéphane Hannaa, Ould MS Abdallahia, Hubert Lepidib, Bernard Gardettec,
Max De Reggia*
a U399 Inserm, université de la Méditerranée, 27, boulevard Jean-Moulin , 13005 Marseille, France
b Laboratoire d’histologie, université de la Méditerranée, 27, boulevard Jean-Moulin, 13005 Marseille, France
c Comex SA, 36, boulevard des océans,13009 Marseille, France
Received 12 January 2001; accepted 25 April 2001
Communicated by Jean Rosa
Abstract – Molecular hydrogen reacts with the hydroxyl radical, a highly cytotoxic
species produced in inflamed tissues. It has been suggested therefore to use gaseous
hydrogen in a new anti-inflammatory strategy. We tested this idea, with the aid of the
equipment and skills of COMEX SA in Marseille, a group who experiments with
oxygen–hydrogen breathing mixtures for professional deep-sea diving. The model used
was schistosomiasis-associated chronic liver inflammation. Infected animals stayed 2
weeks in an hyperbaric chamber in a normal atmosphere supplemented with 0.7 MPa
hydrogen. The treatment had significant protective effects towards liver injury, namely
decreased fibrosis, improvement of hemodynamics, increased NOSII activity, increased
antioxidant enzyme activity, decreased lipid peroxide levels and decreased circulating
TNF-α levels. Under the same conditions, helium exerted also some protective effects,
indicating that hydroxyl radical scavenging is not the only protective mechanism. These
findings indicate that the proposed anti-inflammatory strategy deserves further attention.
© 2001 Académie des sciences/Éditions scientifiques et médicales Elsevier SAS
inflammation / molecular hydrogen / hydroxyl radical / hyperbaric medicine

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