Categories: 肝炎肝硬化脂肪肝肝膿瘍

含氫電解水治療四氯化碳誘導的肝臟損傷

這是來自台灣中山醫科大學的研究，研究發現飲用電解水可以保護小鼠四氯化碳誘導的肝臟損傷。研究採用慢性損傷模型，每天給動物飲用8小時電解水。觀察了肝功能有關的轉氨酶，幾種與抗氧化酶和組織形態學改變。研究結果表明，含氫電解水可減輕四氯化碳誘導的肝臟損傷。研究還有一個肝保護的陽性對照組水飛薊組Silymarin 200 mg/kg)。

過去電解水方面的研究都提出“活性氫”的概念，這個文章用氫氣來解釋，是一個進步。因此把這個文章也在這裡討論。

從研究方法上看，這個文章比較一般，台灣這個學者過去一直研究天然抗氧化物質，有非常多高水平的文章，這個文章很一般，國內許多實驗事都可以很容易實現。而且研究費用也比較少。

Food and Chemical Toxicology

Volume 47, Issue 8 , August 2009, Pages 2031-2036

Hepatoprotective effect of electrolyzed reduced wateragainst carbon tetrachloride-induced liver damage in mice

Chia-Fang Tsai ^a^,¹, Yu-Wen Hsu ^a^,¹, Wen-Kang Chen ^b, Wen-Huei Chang ^c, Cheng-Chieh Yen ^d, Yung-Chyuan Ho ^cand Fung-Jou Lu ^a^,^c^,^e^,^,

^aInstitute of Medicine, College of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., Taichung 402, Taiwan

^bNational Tainan Institute of Nursing, No. 78, Sec. 2, Minzu Rd., Tainan, Taiwan

^cSchool of Applied Chemistry, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., Taichung 402, Taiwan

^dSchool of Occupational Safety and Health, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., Taichung 402, Taiwan

^eDepartment of Nutrition, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., Taichung 402, Taiwan

Received 26 December 2008;

accepted 18 May 2009.

Available online 27 May 2009.

Abstract

The study investigated the protective effect of electrolyzed reduced water (ERW) against carbon tetrachloride (CCl ₄)-induced liver damage. Male ICR mice were randomly divided into control, CCl ₄, CCl ₄+ silymarin, and CCl ₄+ ERW groups. CCl ₄-induced liver lesions include leukocytes infiltration, hepatocyte necrosis, ballooning degeneration, mitosis, calcification, fibrosis and an increase of serum alanine aminotransferase (ALT), and aminotransferase (AST) activity. In addition, CCl ₄also significantly decreased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). By contrast, ERW or silymarin supplement significantly ameliorated the CCl ₄-induced liver lesions, lowered the serum levels of hepatic enzyme markers (ALT and AST) and increased the activities of SOD, catalase, and GSH-Px in liver. Therefore, the results of this study show that ERW can be proposed to protect the liver against CCl ₄-induced oxidative damage in mice, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenging effect.

作者台灣呂鋒洲教授介紹：

http://medicine.csmu.edu.tw/front/bin/ptdetail.phtml?Part=914&Category=23

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