氫氣水可預防卵巢切除後骨質疏鬆
已有 912 次閱讀 2012-11-6 18:39 |個人分類:飲用氫氣水|系統分類:科研筆記|關鍵字:office 3 style
Hydrogen water consumption prevents osteopenia in ovariectomized rats.pdf
來自北京解放軍總醫院的一項研究發現，給去卵巢動物飲用氫氣水可以有效預防骨質疏鬆，論文目前（2012年11月6日）線上發表在《英國藥理學雜誌》上。該課題組曾經報導氫氣對失重引起的骨質疏鬆有預防作用，這應該是其系列研究中的一項。去卵巢手術多見於卵巢腫瘤，卵巢切除可導致雌性激素分泌障礙，導致一系列內分泌異常，當然可以採用激素取代療法進行糾正，另外也可以引起骨質疏鬆，女性更年期後卵巢功能下降也會導致骨質疏鬆。針對這類骨質疏鬆的治療並沒有好的治療和預防手段。許多研究發現，氧化應激也參與骨質疏鬆的形成（這顯然應該是繼發性改變），最近研究發現氫氣作為一種良好的抗氧化物質，可以針對性中和羥基自由基和亞硝酸陰離子，從而產生抗氧化治療作用。本研究工作的目的正是希望確定氫氣是否具有預防卵巢切除後骨質疏鬆的作用。
將切除卵巢的動物餵養氫氣水3月（水中氫氣濃度1.3±0.2 mg/l，1.3 ppm）。然後採集血液和股骨和椎骨進行各類分析。研究結果發現，氫氣水對切除卵巢動物的雌激素水準沒有影響（不太可能有影響？），但可以避免股骨和椎骨骨質減少，包括骨礦物質量和礦物質密度。對卵巢切除後骨骼的極限負荷和剛度等機械應力（翻譯可能不準確），骨小粱體積比、骨小粱數量、骨小粱厚度等影響均有保護作用。對氧化應激和炎症也產生抑制作用，如IL-6和TNFα的mRNA明顯下降，不過股骨eNOS水準和血液NO水準增加。
研究結果說明，氫氣水可以預防因為刺激素剝奪後氧化應激引起的骨質丟失。
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Hydrogen water consumption prevents osteopenia in ovariectomized rats
Accumulating evidence indicates an important role of oxidative stress in the progression of osteoporosis. Recently it was demonstrated that hydrogen gas, as a novel antioxidant, could selectively reduce hydroxyl radicals and peroxynitrite anion to exert potent therapeutic antioxidant activity. The aim of present work was to investigate the effect of hydrogen water consumption on ovariectomy-induced osteoporosis. Ovariectomized rats were fed with hydrogen water (HW, 1.3±0.2 mg/l) for 3 months. Then, blood was collected and femur and vertebrae were removed for evaluation of the effect of HW on bone. HW consumption in ovariectomized rats had no significant effect on estrogen production, but prevented the reduction of bone mass including bone mineral content and bone mineral density in femur and vertebrae, and preserved mechanical strength including ultimate load, stiffness, and energy, and bone structure including trabecular bone volume fraction, trabecular number, and trabecular thickness in femur, and preserved mechanical strength including ultimate load and stiffness, and bone structure including trabecular bone volume fraction and trabecular number in vertebrae. In addition, treatment with HW abated oxidative stress and suppressed IL-6 and TNFα mRNA expressions in femur of ovariectomized rats; treatment with HW increased femur endothelial nitric oxide synthase (eNOS) activity and enhanced circulating nitric oxide (NO) level in ovariectomized rats.Hydrogen water consumption prevents osteopenia in ovariectomized rats possibly through the ablation of oxidative stress induced by estrogen withdrawal.