氫氣治療結腸炎
已有 2835 次閱讀 2009-6-26 20:21 |個人分類:飲用氫氣水|系統分類:科研筆記|關鍵字:氫分子醫學，結腸，炎症，氫氣
這個領域正想我2年前估計的那樣，開始快速發展了，這個研究是針對人類一個非常普遍的疾病：結腸炎，這個疾病不厲害，但嚴重困擾許多人的生活。有這個病的人都有體會。而且治療手段非常缺乏。主要是病因不清楚。但炎症反應是非常確定的。氫治療該疾病只針對炎症，雖然不能針對病因。但也提供了一個非常值得考慮的方法。這個研究非常值得重視。預示著氫分子醫學向更廣泛領域的發展。而且更具有實際意義。
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Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate
Mikihito Kajiyaa, Marcelo J.B. Silvaa, Kimihiro Satob, Kazuhisa Ouharaa and Toshihisa Kawaia,
aDepartment of Immunology, The Forsyth Institute, Boston, MA, USA
bSkyview Enterprises, New York, NY, USA
Received 18 May 2009.
Available online 30 May 2009.
Abstract
By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate (DSS) (5%), (2) DSS (5%) and H2, or (3) H2 only ad libitum up to 7 days. At day-7, DSS-induced pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-α and IL-1β in colon lesion, were significantly suppressed by the addition of H2 to DSS solution. Histological analysis also revealed that the DSS-mediated colonic tissue destruction accompanied by macrophage infiltration was remarkably suppressed by H2. Therefore, the present study indicated that H2 can prevent the development of DSS-induced colitis in mice.
Keywords: Molecular hydrogen; Colitis; Inflammation; Antioxidant; Colon; Dextran sodium sulfate; IL-12; TNF-alpha; IL-1-beta; Macrophages
Article Outline
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Fig. 2. H2-mediated alleviation of colon contraction induced by DSS. To assess the severity of colitis, regular water, H2(0.78 mM) water alone, or 5% DSS with or without H2-water were administered to mice for 7 days after which the colon length was measured. (A) Representative macroscopic features of the colons isolated from mice treated with regular water (Control), H2-containing water (H2), 5% DSS water (DSS) and 5% DSS containing H2-water (H2 + DSS) are shown. (B) The measurement of mean ± SD of colon length in each group at Day-7 is depicted. **p < 0.01: Value differs significantly between the groups indicated by brackets (t-test).
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