氫氣治療apoE基因缺陷動物的動脈硬化 0277086600
已有 3238 次閱讀 2009-2-10 20:20 |個人分類:飲用氫氣水|系統分類:科研筆記|關鍵字:論文，氫氣，抗氧化
這個文章是讓動物從出生開始飲含氫水6個月，發現對動脈硬化具有非常理想的治療效果。
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
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Ikuroh Ohsawaa, b, Kiyomi Nishimakia, Kumi Yamagataa, Masahiro Ishikawaa and Shigeo Ohtaa,
aDepartment of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan
bThe Center of Molecular Hydrogen Medicine, Institute of Development and Aging Sciences, Nippon Medical School, Kawasaki 211-8533, Japan
Received 16 October 2008.
Available online 6 November 2008.
Abstract
Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H2) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat. Med. 13 (2007) 688–694]. Here, we investigated whether drinking H2-dissolved water at a saturated level (H2–water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE−/−), a model of the spontaneous development of atherosclerosis. ApoE−/− mice drank H2–water ad libitum from 2 to 6 month old throughout the whole period. Atherosclerotic lesions were significantly reduced by ad libitum drinking of H2–water (p = 0.0069) as judged by Oil-Red-O staining series of sections of aorta. The oxidative stress level of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H2-dissolved water has the potential to prevent arteriosclerosis.
Keywords: Antioxidant; ApoE; Arteriosclerosis; Atherogenesis; Dihydrogen; Lifestyle-related disease; Macrophage; Molecular hydrogen; Oxidative stress; Preventive medicine
Article Outline
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