新型含氫氣透析液(當心假氫水破財又傷身)

新型含氫氣透析液

已有2350次閱讀 2010-5-20 17:59 | 個人分類: 氫氣醫學臨床 | 系統分類: 觀點評述 | 關鍵詞:氫氣，透析

加氫氣的新型血液透析的臨床研究

長期血液透析引起的慢性炎症是預後不良的重要原因。但是，治療長期血液透析引起的慢性炎症的手段非常有限。許多動物實驗結果發現，氫氣具有器官氧化和炎症損傷的良好保護作用。我們用含氫氣電解液開發出新型血液透析系統，並進行了臨床效應觀察。用電解方法製備氫氣並將氫氣溶解到反滲水中並和透析液混合，氫氣濃度可達到48 ppb 。受試對象為病情穩定使用常規透析液治療的21 名患者，換用新含氫氣透析液6 月，每週三次治療。結果發現，在治療過程中，沒有任何明顯的不良反應，比較突出的效果是，透析後血壓正常比例明顯增加，治療前只有21% 收縮壓低於140 mmHg ，而新透析後達到62% ，有顯著統計學區別。雖然透析相關指標沒有明顯變化（透析效果無區別？），但血液中代表炎症反應的MCP1 和MPO 顯著下降。該研究表明，加氫氣新型透析液對血壓控制效果良好，並能有效控制炎症反應。該新型透析液給尿毒症患者帶了福音。要知道，這種新型透析液成本並不增加多少。

Nephrol Dial Transplant. 2010 Apr 12. [Epub ahead of print]

A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial.

Nakayama M , Nakano H , Hamada H , Itami N , Nakazawa R , Ito S .

1 Tohoku University Hospital, Department of Blood Purification (Sendai).

Abstract

Background. Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects. Methods. Dialysis solution with H(2) (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H(2) generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week. Results. During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified. Conclusions. Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.

PMID: 20388631 [PubMed – as supplied by publisher]

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歡迎來電索取氫水辨認方法(防止喝到傷身的假氫水)

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