Categories: 孫學軍醫師文獻

氫分子醫學的新啟示：一些臨床藥物的奇怪作用

氢分子医学的新启示：一些临床药物的奇怪作用

这个观点实际上与我去年的文章是类似的，我们去年提出的观点是内源性氢是一种抗氧化物质，这个文章的观点是有些糖尿病药物，可抑制能量物质吸收，有一个明显的副作用是大肠内产生气体，这类药物往往具有器官保护作用。过去一直不明白为什么这样。日本学者提出的这个观点，我是非常同意。过去1年我们课题组多次讨论到这个话题。可惜我们没有把这个观点形成文章。真的十分可惜。

Hypothesis

Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

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Yoshihiko Suzuki^a, Motoaki Sano^c^,^,, Kentaro Hayashida^c, Ikuroh Ohsawa^a^,^b, Shigeo Ohta^a and Keiichi Fukuda^c

^aDepartment of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

^bThe Center of Molecular Hydrogen Medicine, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

^cDepartment of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160-8582, Japan

Received 20 April 2009;

revised 28 May 2009;

accepted 31 May 2009.

Available online 8 June 2009.

Abstract

The major side-effect of treatment with α -glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of α -glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H ₂in the gastrointestinal tract. Acarbose, which is an α -glucosidase inhibitor, markedly increased H ₂production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H ₂acts as a unique antioxidant, and that when inhaled or taken orally as H ₂-dissolved water it ameliorates ischaemia–reperfusion injury and atherosclerosis development.

Keywords: α -Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant

Article Outline

1. Introduction
2. Molecular hydrogen (H ₂) acts as a novel antioxidant
3. Unexpected benefit of flatulence caused by α -glucosidase inhibitors
4. Conclusion
Conflict of interest statement
Acknowledgements
References

Corresponding author. Address: Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Fax: +81 3 5363 3875.

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