低氘氫水實驗室 研究項目

  1. 極超高純氫氣研究—7N、8N維米製程氫氣
  2. 固態儲氫器研究、太空船用固態儲氫器研究
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  7. 氫氣用於食品科學研究
  8. 低氘水用於食品科學研究
  9. 呼吸氫氣及低氘飽和氫水之於癌症、中風、巴金森症、妥瑞症、糖尿病、心肌損傷、肝損傷、腦中風、放射治療損傷、老年癡呆、心肌硬塞、痛風、COPD、異位性皮膚炎、僵直性脊椎炎、過敏、紅斑性狼瘡及自體免疫性疾病之觀察研究


氫分子醫學的新啟示:一些臨床藥物的奇怪作用

氢分子医学的新启示:一些临床药物的奇怪作用

这个观点实际上与我去年的文章是类似的,我们去年提出的观点是内源性氢是一种抗氧化物质,这个文章的观点是有些糖尿病药物,可抑制能量物质吸收,有一个明显的副作用是大肠内产生气体,这类药物往往具有器官保护作用。过去一直不明白为什么这样。日本学者提出的这个观点,我是非常同意。过去1年我们课题组多次讨论到这个话题。可惜我们没有把这个观点形成文章。真的十分可惜。

 

Hypothesis

 

 

Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

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Yoshihiko Suzukia, Motoaki Sanoc, Corresponding Author Contact Information, E-mail The Corresponding Author, Kentaro Hayashidac, Ikuroh Ohsawaa, b, Shigeo Ohtaa and Keiichi Fukudac

aDepartment of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

bThe Center of Molecular Hydrogen Medicine, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan

cDepartment of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160-8582, Japan

Received 20 April 2009; 

revised 28 May 2009; 

accepted 31 May 2009. 

Available online 8 June 2009.

 

 

 

Abstract

The major side-effect of treatment with α -glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of α -glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H 2in the gastrointestinal tract. Acarbose, which is an α -glucosidase inhibitor, markedly increased H 2production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H 2acts as a unique antioxidant, and that when inhaled or taken orally as H 2-dissolved water it ameliorates ischaemia–reperfusion injury and atherosclerosis development.

Keywords: α -Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant

Article Outline

1. Introduction
2. Molecular hydrogen (H 2) acts as a novel antioxidant
3. Unexpected benefit of flatulence caused by α -glucosidase inhibitors
4. Conclusion
Conflict of interest statement
Acknowledgements
References

Corresponding Author Contact InformationCorresponding author. Address: Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Fax: +81 3 5363 3875.

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低氘氫水實驗室

低氘氫水實驗室

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