氫氣對慶大黴素誘導的腎臟毒具有保護作用
已有 1234 次閱讀 2011-10-7 09:58 |個人分類:飲用氫氣水|系統分類:科研筆記|關鍵字:慶大黴素 white style class www.h2-water.com
這個小組前段時間剛發表了順鉑腎臟毒性的保護作用，採用血氧依賴的MRI技術研究，研究手段幾乎沒有什麼區別，只是換了一下動物模型，本來我開始以為是同一個研究，結果沒有注意，但仔細一看，原來是不同的研究。這個研究特別強調了一種避免氫氣從飼養瓶洩露的方法，就是在金屬管內放了兩個小球。大家不要被這個東西給糊弄了，因為氫氣在水中的溶解度只有2%，濃度的降低並不是通過瓶口的釋放，而是在瓶子內釋放到氣墊中，如果希望減少氫氣濃度的降低，唯一的辦法是採用軟質包裝，避免氣泡形成。否則的話是沒有任何意義的。我想他們肯定沒有進行濃度的對比檢測，否則不會把這個內容寫到文章中，
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http://www.jstage.jst.go.jp/article/mrms/10/3/169/_pdf
Magn Reson Med Sci. 2011;10(3):169-76.
Protective Effect of Hydrogen-rich Water against Gentamicin-induced Nephrotoxicity in Rats using Blood Oxygenation Level-dependent MR Imaging.
Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K.
Source
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University.
Abstract
Purpose: We assessed intrarenal oxygenation in gentamicin-induced nephrotoxicity (GIN) and the protective effect of hydrogen-rich water (HW) against GIN using blood oxygenation level-dependent magnetic resonance (MR) imaging. Materials and Methods: We acquired T(2)*-weighted images (T(2)*WI) of 21 rats on Days 0, 2, 4, and 7 using a 1.5-tesla MR imaging system. The rats were divided into 3 groups of seven each: control rats had free access to standard water and no gentamicin (GM) injection; rats designated the GM group had free access to standard water and were injected with GM (80 mg/kg/day) subcutaneously for 7 days; and the third group, designated the GM+HW group, had free access to HW and were injected with GM. R(2)* (=1/T(2)*) was estimated from T(2)*WI. Results: R(2)* values in the cortex were significantly decreased on Days 2, 4, and 7 compared with those on Day 0 in the GM group but not significantly changed in the control and GM+HW groups. R(2)* values in the medulla did not change significantly in any group. Conclusions: Our findings suggested reduced oxygen utility, mainly in the cortex, in gentamicin-induced nephrotoxicity and an ameliorative effect of hydrogen-rich water against GIN.