含氫氣水沐浴可對抗紫外線
已有 730 次閱讀 2013-4-9 11:20 |個人分類:飲用氫氣水|系統分類:科研筆記|關鍵字:紫外線 對抗
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The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury i.pdf
紫外線可以導致皮膚損傷，並可以導致DNA損傷甚至可以誘發皮膚腫瘤，由於紫外線引起的皮膚損傷主要是紫外線引起的氧化損傷和局部炎症反應，因此採用抗氧化物質治療紫外線皮膚損傷是一種治療選擇，但是一般抗氧化物質難以進入細胞內所有部位，限制了許多抗氧化物質的作用。氫氣是一種特殊的選擇性抗氧化物質，使用呼吸、注射氫氣溶液和飲用的方式可以治療多種氧化和炎症相關疾病，來自韓國的一個小組最近報導了使用氫氣水沐浴對紫外線引起的小鼠皮膚損傷具有理想的治療效果，這種治療作用和減少氧化損傷、炎症反應有關係，而且發現可以增加皮膚本身的抗氧化物質如谷胱甘肽含量。韓國學者曾經報導過氫氣水沐浴對人類皮膚皺紋產生具有對抗作用，這裡採用動物模型，進一步證明這種作用，並探討了部分分子機制。
該文章最近線上發表在Mol Cell Toxicol (2013) 9:15-21，前幾天，來自國內南京醫科大學的小組也證明採用注射氫氣生理鹽水對這類損傷的治療作用。雖然從本質上研究都是探討氫氣對抗紫外線皮膚損傷的研究，但通過沐浴的方法具有更大的可行性和實用性。
研究中設計了三種治療組，分別是普通鹼性電解水，低濃度氫氣水和高濃度氫氣水，雖然低濃度氫氣水的還原性（ORP）比普通鹼性電解水低，但從各類指標上看，氫氣水的效果比鹼性電解水更理想。研究缺少應該有的對照，例如非紫外線照射組、單純沐浴組。限制了該研究的客觀性和全面性。
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The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice
Rosa Mistica Ignacio1, Yang-Suk Yoon1, Ma. Easter Joy Sajo1, Cheol-Su Kim2, Dong-Heui Kim1, Soo-Ki Kim2 & Kyu-Jae Lee1,3
Received: 23 August 2012 / Accepted: 8 February 2013
�The Korean Society of Toxicogenomics and Toxicoproteomics and Springer 2013
1Department of Environmental Medical Biology, Wonju College of
Medicine, Yonsei University, Wonju-si, Gangwon-do 220-701, Korea
2Department of Microbiology, Wonju College of Medicine,
Yonsei University, Wonju-si, Gangwon-do 220-701, Korea
3Institute for Poverty Alleviation and International Development,
Yonsei University Wonju Campus, Wonju-si, Gangwon-do 220-710,
Korea
Correspondence and requests for materials should be addressed to
K. J. Lee ( medbio9@gmail.com) &
S. K. Kim ( kim6@yonsei.ac.kr)
相關研究資料
Materials & Methods Preparation of HRW and ARW Hydrogen reduced water (HRW) was generated from electrolyzing apparatus. pH and oxidative reduction potential (ORP) values of HRW were adjusted to obtain weak HRW(w-HRW) and strong HRW(s-HRW) as seen in Table 1. Alkaline reduced water(ARW) was produced by the continuously electrolyzing apparatus (HDr Co., Ltd., Korea). Main source of water was a tap water. ARW was prepared by physical filtering followed by electrolysis and collected in a cell equipped with a cathode platinum-coated titanium electrode (0.9±0.1 A, 1-2 L/min at 2 kgf/min). We used tapwater (TW) for positive control group. The characteristics of test waters were adjusted in terms of pH, oxidation
reduction potential (ORP) and temperature (Table 1).
Animals
Six-week old male SKH-1 hairless mice weighing 25 ±2 g were purchased from Orient Bio Inc. (Korea). Mice were maintained in stainless steel cages in a controlled environment with temperature of 22±2�C and 40-60% humidity under a 12 : 12 hour light dark cycle.
After 1 week of acclimation, the hairless mice were randomly assigned to four groups: TW-bathing group bathed with tap water after UV treatment (control, n=12), ARW-bathing group bathed in ARW after UV treatment (n=12), w-HRW-bathing group bathed with
weak HRW after UV treatment and s-HRW-bathing group bathed in strong HRW after UV treatment. The animal use and care protocol for this animal experiment was approved by the Institutional Animal Care and Use Committee (IACUC) at Wonju Campus, Yonsei University, Wonju, Gangwon, Korea.
UVB irradiation and bathing
UVB fluorescent lamp (TL 40W/12RS Philips, Netherland Holland) emitting a continuous spectrum between 290-320 nm was used to induce skin damage. The intensity of UVB lamp was 0.10-0.15 mW/cm2 and the total cumulative dose energy of UVB irradiated was 360-540 mJ/cm2 (UV light meter YK-34 UV, Lutron Electronics Inc., Taiwan). The lamp was mounted 30 cm above surface of the bathing cage. TW-bath- Mol Cell Toxicol (2013) 9:15-21 19
Table 1. Preparation of test water.
Test water pH ORP Temperature
w-HRW 7.33±0.53 -83.3±44.8 30.0±0.3
s-HRW 7.32±0.34 -481±41.4 30.0±0.4
ARW 9.88±0.28 -225±117 30.5±0.4
TW 6.90±0.35 410±166 29.9±0.1
Abbreviations: w-HRW, weak-hydrogen reduced water; s-HRW, strong-hydrogen reduced water; ARW, alkaline reduced water; TW, tap water; ORP, oxidation reduction potential