低氘氫水實驗室 研究項目
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- 低氘飽和氫水製程研究及應用研究
- 低氘水用於生物實驗及製藥應用研究
- 氫氣呼吸之劑量及物理效應研究
- 低氘水用於育苗育種農業生技研究
- 氫氣用於食品科學研究
- 低氘水用於食品科學研究
- 呼吸氫氣及低氘飽和氫水之於癌症、中風、巴金森症、妥瑞症、糖尿病、心肌損傷、肝損傷、腦中風、放射治療損傷、老年癡呆、心肌硬塞、痛風、COPD、異位性皮膚炎、僵直性脊椎炎、過敏、紅斑性狼瘡及自體免疫性疾病之觀察研究
本文提到氫的問題,從自由基的角度分析氫的生物學效應
Forgotten Radicals in Biology
Rochette Luc, Catherine Vergely
Laboratoire De Physiopathologie Et Pharmacologie Cardiovasculaires Experimentales,
Facultes De Medecine Et Pharmacie, Dijon Cedex, France
Abstract
Redox reactions play key roles in intra- and inter-cellular signaling, and in adaptative processes of tissues
towards stress . Among the major free radicals with essential functions in cells are reactive oxygen species
(ROS) including superoxide anion (O2
•-), hydroxyl radical (•OH) and reactive nitrogen species (RNS) such as
nitric oxide (•NO). In this article, we review the forgotten and new radicals with potential relevance to cardiovascular
pathophysiology. Approximately 0.3% of O2
•- present in cytosol exists in its protonated form: hydroperoxyl
radical (HO2
•). Water (H2O) can be split into two free radicals: •OH and hydrogen radical (H•). Several
free radicals, including thiyl radicals (RS •) and nitrogen dioxide (NO2
•) are known to isomerize double
bonds. In the omega-6 series of poly-unsaturated fatty acids ( PUFAs), cis-trans isomerization of γ-linolenate
and arachidonate catalyzed by RS • has been investigated. Evidence is emerging that hydrogen disulphide
(H2S) is a signaling molecule in vivo which can be a source of free radicals. The Cu-Zn superoxide dismutase
(SOD) enzyme can oxidize the ionized form of H2S to hydro-sulphide radical: HS•. Recent studies suggest
that H2S plays an important function in cardiovascular functions. Carbonate radical, which can be formed
when •OH reacts with carbonate or bicarbonate ions , is also involved in the activity of Cu-Zn-SOD. Recently,
it has been reported that carbonate anion were potentially relevant oxidants of nucleic acids in physiological
environments. In conclusion, there is solid evidence supporting the formation of many free radicals by cells
leading which may play an important role in their homeostasis. (Int J Biomed Sci 2008; 4(4):255-259)
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