氫氣是新的具有潛在臨床應用的氣體

13 4 月, 2010
作者: 低氘氫水實驗室
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在腎臟國際雜誌上，最近有一篇評論文章，題目是“氫氣：另一個具有治療潛力的氣體”。該文章是對同一雜誌美國匹大移植中心關於含氫水治療移植後腎病論文的評論。這是目前美國對氫氣研究最前沿的小組，負責人是日裔教授Nakao，他們已經先後發表了氫氣對小腸、心臟和腎臟移植方面的文章，可以說是移植與氫氣方面具有特點。這個評論文章沒有看到全文，從摘要看沒有什麼值得看的內容。

本文的日文全文

[PDF] 水素―新しい治療的醫學ガスhra-japan.org [PDF]
JF George, A Agarwal – hra-japan.org
Page 1.編集者の論評（掲載論文の解説）水素―新しい治療的醫學ガスJames F.
George1,3 and Anupam Agarwal2,3 1Department of Surgery, Division of Cardiothoracic
Surgery and the 2Department of Medicine, Division of Nephrology…

全文已經獲得，請 下載

Hydrogen: another gas with therapeutic potential

James F George & Anupam Agarwal

Abstract

Cardinal and colleagues describe the use of molecular hydrogen, the most abundant molecule in the universe, as a treatment for chronic allograft nephropathy (CAN) in a rat model of kidney transplantation. They demonstrate that the addition of hydrogen to the drinking water results in a decrease in the severity of CAN and increased graft survival, and they provide evidence that the mechanism of action could be due to a reduction in reactive oxygen species. Kidney International (2010) 77, 85–87. doi:10.1038/ki.2009.432

圖中的觀點需要商榷，氫氣目前不能證明能中和超氧自由基。

Given
previous data, the interpretation that the
benefi cial eff ects of H 2 in a kidney transplant
model are a result of antioxidant
properties of the element is reasonable
and likely. However, this may not be the
sole explanation, and other as-yet undefi
ned mechanisms may be involved. Th e
presence of basal levels of H 2 indicates one
or more endogenous sources, suggesting
that it plays a physiological role. Precedent
for this possibility can be easily found in
other gas-generating systems.

Therefore, given the
increasing number of systems in which H 2
is being shown to mediate beneficial
eff ects, and likely, in the future, deleterious
ones as well, it is probable that involvement
of H 2 in signaling pathways or other
physiological functions will be found.

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