低氘氫水實驗室 研究項目

  1. 極超高純氫氣研究—7N、8N維米製程氫氣
  2. 固態儲氫器研究、太空船用固態儲氫器研究
  3. 低氘飽和氫水製程研究及應用研究
  4. 低氘水用於生物實驗及製藥應用研究
  5. 氫氣呼吸之劑量及物理效應研究
  6. 低氘水用於育苗育種農業生技研究
  7. 氫氣用於食品科學研究
  8. 低氘水用於食品科學研究
  9. 呼吸氫氣及低氘飽和氫水之於癌症、中風、巴金森症、妥瑞症、糖尿病、心肌損傷、肝損傷、腦中風、放射治療損傷、老年癡呆、心肌硬塞、痛風、COPD、異位性皮膚炎、僵直性脊椎炎、過敏、紅斑性狼瘡及自體免疫性疾病之觀察研究

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氫氣可治療老年性癡呆

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LTP
電生理指標,確定了治療效果,這個研究的指標和新意都比較突出,發表在 BR上比較委屈。將來這個文章將會有比較好的引用情況。因為這個領域將是比較重要的研究方向。一是這個疾病比較重要,另一個是抗炎症是這個疾病將來比較有前途的治療手段。如果氫氣在這個疾病能得到臨床證據,將是比較有前景的。

這個工作具有非常好的原始創新性。值得閱讀,值得關注,值得推薦。

 

日本醫科大學太田小組目前也在開展老年性癡呆氫氣水治療的研究,他們在剛舉行的學術會議中已經介紹了該工作。我們這個研究是採用腦內註射 amyloid β的癡呆模型,腹腔注射氫氣鹽水,採用炎症因子測定,行為學評價,氧化損傷指標和 

 

Hydrogen-rich Saline Improves Memory Function in a Rat Model of Amyloid-beta-induced Alzheimer’s Disease by Reduction of Oxidative Stress

 

Jian LI , Cai WANG , John H. Zhang , Jian-mei CAI , Yun-peng CAO , Xue-jun SUN c

 

Department of Neurology, the first affiliated hospital of China Medical University, Shengyang 110001, China; Department of Neurosurgery, Loma Linda University, California, CA, USA; cDepartment of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China

 

Corresponding authors: Yun-peng CAO, Department of neurology, First afflicted Hospital, ChinaMedical University, Shenyang, 110001, PR China.

Telephone: (86)2483282516, Fax: (86)2483282385. E-mail: ypengcao@yahoo.com;

Xue-jun Sun, Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, PR China. Tel: (86)2125070349. Fax: (86)2165492382. Email: sunxjk@hotmail.com

Abstract

This study is to examine if hydrogen-rich saline reduced amyloid β (Aβ) induced neural inflammation, and learning and memory deficits in a rat model. SD male  rats (n = 84, 280 -330g) were divided into three groups, sham operated, Aβ1 -42 injected and Aβ1-42 plus hydrogen-rich saline treated animals. Hydrogen-rich saline ( 5 ml/kg, ip, daily ) was injected for 14 days after intracerebroventricular injection of Aβ1-42. The levels of MDA, IL-6 and TNF-α were assessed by biochemical and ELISA analysis. Morris Water Maze and open field task were used to assess the memory dysfunction and motor dysfunction, respectively. LTP were used to detect the electrophysiology changes, HNE and GFAP immunohistochemistry were used to assess the oxidative stress and glial cell activation. After Aβ1-42 injection, the levels of MDA, IL-6, and TNF-α were increased in brain tissues and hydrogen-rich saline treatment suppressed MDA, IL-6, and TNF-α concentration. Hydrogen-rich saline treatment improved Morris Water Maze and enhanced LTP in hippocampus blocked by Aβ1-42. Furthermore, hydrogen-rich saline treatment also decreased the immunoreactivitiy of HNE and GFAP in hippocampus induced by Aβ1-42. In c onclusion ,hydrogen-rich saline prevented Aβ-induced neuroinflammation and oxidative stress, which may contribute to the improvement of memory dysfunction in this rat model.

 

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低氘氫水實驗室

低氘氫水實驗室

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