低氘氫水實驗室 研究項目

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  9. 呼吸氫氣及低氘飽和氫水之於癌症、中風、巴金森症、妥瑞症、糖尿病、心肌損傷、肝損傷、腦中風、放射治療損傷、老年癡呆、心肌硬塞、痛風、COPD、異位性皮膚炎、僵直性脊椎炎、過敏、紅斑性狼瘡及自體免疫性疾病之觀察研究

氫氣治療結腸炎

 

這個領域正想我2年前估計的那樣，開始快速發展了，這個研究是針對人類一個非常普遍的疾病：結腸炎，這個疾病不厲害，但嚴重困擾許多人的生活。有這個病的人都有體會。而且治療手段非常缺乏。主要是病因不清楚。但炎症反應是非常確定的。氫治療該疾病只針對炎症，雖然不能針對病因。但也提供了一個非常值得考慮的方法。這個研究非常值得重視。預示著氫分子醫學向更廣泛領域的發展。而且更具有實際意義。

Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate

 

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Mikihito Kajiya a , Marcelo JB Silva a , Kimihiro Sato b , Kazuhisa Ouhara a and Toshihisa Kawai a, Corresponding Author Contact Information, E-mail The Corresponding Author

 

a Department of Immunology, The Forsyth Institute, Boston, MA, USA

b Skyview Enterprises, New York, NY, USA

Received 18 May 2009. 
Available online 30 May 2009. 

 

Abstract

By its antioxidant effect, molecular hydrogen gas (H 2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate (DSS) (5%), (2) DSS (5%) and H 2, or (3) H 2only ad libitum up to 7 days. At day-7, DSS-induced pathogenic outcomes including , loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-α and IL-1β in colon lesion, were significantly suppressed by the addition of H 2to DSS solution. Histological analysis also revealed that the DSS-mediated colonic tissue destruction accompanied by macrophage infiltration was remarkably suppressed by H 2. Therefore, the present study indicated that H 2can prevent the development of DSS-induced colitis in mice.

Keywords: Molecular hydrogen; Colitis; Inflammation; Antioxidant; Colon; Dextran sodium sulfate; IL-12; TNF-alpha; IL-1-beta; Macrophages

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Fig. 2. H 2-mediated alleviation of colon contraction induced by DSS. To assess the severity of colitis, regular water, H 2(0.78 mM) water alone, or 5% DSS with or without H 2-water were administered to mice for 7 days after which the colon length was measured. (A) Representative macroscopic features of the colons isolated from mice treated with regular water (Control), H 2-containing water (H 2), 5% DSS water (DSS) and 5% DSS containing H 2– water (H 2+ DSS) are shown. (B) The measurement of mean ± SD of colon length in each group at Day-7 is depicted. ** p < 0.01: Value differs significantly between the groups indicated by brackets (t-test ).
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