低氘氫水實驗室 研究項目

  1. 極超高純氫氣研究—7N、8N維米製程氫氣
  2. 固態儲氫器研究、太空船用固態儲氫器研究
  3. 低氘飽和氫水製程研究及應用研究
  4. 低氘水用於生物實驗及製藥應用研究
  5. 氫氣呼吸之劑量及物理效應研究
  6. 低氘水用於育苗育種農業生技研究
  7. 氫氣用於食品科學研究
  8. 低氘水用於食品科學研究
  9. 呼吸氫氣及低氘飽和氫水之於癌症、中風、巴金森症、妥瑞症、糖尿病、心肌損傷、肝損傷、腦中風、放射治療損傷、老年癡呆、心肌硬塞、痛風、COPD、異位性皮膚炎、僵直性脊椎炎、過敏、紅斑性狼瘡及自體免疫性疾病之觀察研究

Email: ddh2water@gmail.com

Line ID: @drh2 點此加好友



氫水還原健康-氫氣可治療慢性移植腎病

 

This was recently accepted in Kidney International(Impact factor 6.8).

隨著免疫抑製藥物的發展,腎移植急性排斥反應基本上都可以得到控制,但慢性移植腎病尚無明確有效的治療藥物和方法。慢性移植腎病是導致移植腎晚期功能喪失的最主要原因。

慢性移植腎病的發病機制目前比較公認的觀點是:本病是由異種抗原依賴的免疫因素(如急性排斥反應、免疫抑製劑不足等)及非異種抗原依賴的因素(如延長的冷缺血時間、供體年齡、受體脂代謝異常、高血壓、糖尿病或糖耐量異常、移植後612月間腎功能受損、钜細胞病毒感染等)導致的移植腎功能持續惡化和發展。本文作者最近在Fisher344Lewis大鼠慢性移植腎病模型發現:成年鼠間腎移植的慢性移植腎病顯著比幼年鼠間腎移植的慢性移植腎病嚴重。

本研究通過動物腎臟移植模型,持續給含氫水150天,比較了腎臟功能、死亡率、炎症因數和MAPK系統,證明含氫水可以治療慢性移植腎病,這個研究給臨床上治療該疾病帶來了新的希望。也是氫分子醫學方面的又一力作。

ORAL ADMINISTRATION OF HYDROGEN WATER PREVENTS CHRONIC

ALLOGRAFT NEPHROPATHY IN RAT RENAL TRANSPLANTATION

 

ABSTRACT: (210 words)

Tissue injury, induced by reactive oxygen species (ROS), contributes to the development of chronic allograft nephropathy (CAN; also known as interstitial fibrosis and tubuar atrophy with unknown etiology [IF/TA]) after renal transplantation. Molecular hydrogen gas can act as a ROS scavenger. We hypothesized that administration of hydrogen water (HW) would ameliorate CAN by scavenging ROS. Using a rat model of kidney transplantation, LEW rat allografts were orthotopically transplanted into BN rat recipients that had undergone bilateral nephrectomy .

Molecular hydrogen was dissolved in water (> 0.8 mM ) and recipients were given either regular water (RW) or HW from day 0 to day 150, or death. RW-treated animals experienced a gradual decline in creatinine clearance, associated with proteinuria, which ultimately led to graft failure secondary to CAN. In contrast, HW administration improved allograft function, slowed the

progression of CAN, and improved overall survival. HW also reduced oxidant injury and inflammatory mediator production. Additionally, inflammatory signaling pathways (mitogen activated protein kinases ) were less activated in renal allografts from HW-treated rats compared to the RW-treated group. These data indicate that orally administered HW is an effective antioxidant and anti-inflammatory agent that can prevent CAN and improve survival in a model of rodent renal transplantation . HW may be of therapeutic value in the setting of transplantation.

 

 


 

  

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email: ddh2water@gmail.com

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歡迎來電索取氫水辨認方法(防止喝到傷身的假氫水) 

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提供玻璃瓶裝飽和氫水供對比,免費兩瓶給你測試,收運費120元。(運費是宅配業者收去的)

 

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低氘氫水實驗室

低氘氫水實驗室

TEL: 0963-788-693
Email: ddh2water@gmail.com
Line ID:@drh2 點此加好友(加Line優先回覆)
台灣氫水實驗室部落格: http://blog.xuite.net/hworker77086600/twblog
FB氫友團:https://www.facebook.com/groups/301217133566722
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歡迎點此申請索取氫水辨認方法(防止喝到傷身的假氫水)提供玻璃瓶裝飽和氫水供對比,免費兩瓶給你測試,收運費120元。(運費是宅配業者收去的)

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