低氘氫水實驗室

學者孫學軍 發表於2010-3-28 10:13:05

氫氣分子醫學熱點論文介紹

瞭解一個領域，首先必須認真深入學習該領域的經典論文，那些屬於經典論文，需要這個領域的重量級人物才能給一個比較準確的答案。不過，從引用率上可以簡單看到熱點論文，這是每個人都能很容易檢索到的。為了方便初學者迅速掌握這個領域的最重要論文。這個對熱點論文進行介紹。將來可能追加一些經典論文。

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic …

I Ohsawa, M Ishikawa, K Takahashi, M Watanabe, K … – Nature medicine, 2007 – nature.com
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage
to tissues, and persistent oxidative stress is accepted as one of the causes of many common
diseases including cancer. We show here that hydrogen (H 2 ) has potential as an …
被引用次數：76 – 相關文章

這個文章是屬於bible級的論文，從引用量上可以看出了。該論文首先在國際上公佈呼吸2%的氫氣可以治療腦缺血在灌注損傷，分別從動物模型、各種細胞學、和化學反應等層面，證明氫氣是選擇性與毒性自由基直接反應，從而具有抗氧化損傷的作用。從該研究出發，非常容易能引申出呼吸氫氣對其他各類器官再灌注損傷，各類炎症反應可能具有治療作用。

這個發表在Nature medicines上的文獻將是該領域永遠熱點論文，幾乎所有的文章都引用它。

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial …

K Hayashida, M Sano, I Ohsawa, K Shinmura, K … – Biochemical and …, 2008 – Elsevier
Inhalation of hydrogen (H 2 ) gas has been demonstrated to limit the infarct volume of brain and
liver by reducing ischemia–reperfusion injury in rodents. When translated into clinical
practice, this therapy must be most frequently applied in the treatment of patients with …
被引用次數：38 – 相關文章 – 所有 6 個版本

來自同一個實驗室。屬於第一篇的姐妹篇，唯一的區別是採用心臟缺血模型。發表雜誌BBRC

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/ …

h4o.jp [PDF]
K Fukuda, S Asoh, M Ishikawa, Y Yamamoto, I … – Biochemical and …, 2007 – Elsevier
We have recently showed that molecular hydrogen has great potential for selectively reducing
cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen
gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. …
被引用次數：34 – 相關文章 – 所有 13 個版本

來自同一個實驗室。屬於第一篇的姐妹篇，唯一的區別是採用肝臟缺血模型。

注意這是2007年的文章。發表雜誌BBRC

[PDF] Hydrogen inhalation ameliorates oxidative stress in transplantation induced …

sciencetimes.com.cn [PDF]
BM Buchholz, DJ Kaczorowski, R Sugimoto, R … – Am J …, 2008 – sciencetimes.com.cn
Ischemia/reperfusion (I/R) injury during small intesti- nal transplantation (SITx) frequently causes
complica- tions including dysmotility, inflammation and organ failure. Recent evidence indicates
hydrogen inhalation eliminates toxic hydroxyl radicals. Syngeneic, ortho- topic SITx was …
被引用次數：32 – 相關文章 – HTML 版 – 所有 22 個版本

這個文章的特點：美國第一篇，選擇的器官是小腸，選擇的模型是移植，選擇的指標是炎症反應。這三個特點決定了這個文獻將是該領域的熱點論文。

[PDF] Supplementation of hydrogen-rich water improves lipid and glucose …

watersurvey.org [PDF]
S Kajiyama, G Hasegawa, M Asano, H … – … BALANCE: ROLE IN …, 2008 – watersurvey.org
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with
type 2 diabetes or impaired glucose tolerance Sizuo Kajiyama a, b, Goji Hasegawa b,?, Mai
Asano b, Hiroko Hosoda b, Michiaki Fukui b, Naoto Nakamura b, Jo Kitawaki c, Saeko …
被引用次數：25 – 相關文章 – HTML 版 – 所有 25 個版本

是喝8周含氫氣水對糖尿病患者脂肪和糖代謝影響的初步觀察。這個文獻的特點是該領域的第一篇人體試驗，這決定了該文獻的重要地位。

Consumption of molecular hydrogen prevents the stress-induced impairments in …

sciencenet.cn [PDF]
K Nagata, N Nakashima-Kamimura, T Mikami, … – …, 2008 – nature.com
We have reported that hydrogen (H 2 ) acts as an efficient antioxidant by gaseous rapid
diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach
of a rat, hydrogen was detected at several M level in blood. Because hydrogen gas is …
被引用次數：23 – 相關文章 – 所有 22 個版本

該文章是用含氫氣水對大鼠應激後神經損傷的治療作用，特點是對該領域從缺血再灌注向應激後損傷進行了擴展。實驗中觀察了海馬損傷與神經再生。發表在神經精神藥理學雜誌上。

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin …

sciencenet.cn [PDF]
Y Sato, S Kajiyama, A Amano, Y Kondo, T … – Biochemical and …, 2008 – Elsevier
Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism
of hydrogen’s effect in the brain, we administered hydrogen-rich pure water (H 2 ) to senescence
marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot …
被引用次數：19 – 相關文章 – 所有 14 個版本

這個文章的重要性是對氫氣的選擇性抗氧化提出了挑戰，但聲音不強。動物模型是比較特殊的。發表在BBRC

Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model

159.226.26.14 [PDF]
J Cai, Z Kang, WW Liu, X Luo, S Qiang, JH Zhang, S … – Neuroscience …, 2008 – Elsevier
Hypoxia–ischemia (HI) brain injury is a major cause of neuronal cell death especially apoptosis
in the perinatal period. This study was designated to examine the effect of hydrogen therapy
on apoptosis in an established neonatal HI rat pup model. Seven-day-old rat pups were …
被引用次數：17 – 相關文章 – 所有 11 個版本

這個文章採用不同的腦缺血模型，證明呼吸氫氣對新生兒腦缺血具有治療作用。重要的是，這是除日本美國以外的地區發表的第一篇論文。

Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E …

I Ohsawa, K Nishimaki, K Yamagata, M … – Biochemical and …, 2008 – Elsevier
Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants
failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen
(dihydrogen; H 2 ) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, …
被引用次數：14 – 相關文章 – 所有 5 個版本

這個文章是對動脈硬化的治療作用，擴展了研究領域。發表在BBRC

Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model

sciencenet.cn [PDF]
J Cai, Z Kang, K Liu, WW Liu, RP Li, JH Zhang, X Luo, … – Brain research, 2009 – Elsevier
Cerebral hypoxia–ischemia (HI) represents a major cause of brain damage in the term
newborn. This study aimed to examine the short and long-term neuroprotective effect of hydrogen
saline (H 2 saline) using an established neonatal HI rat pup model. Seven-day-old rat …
被引用次數：9 – 相關文章 – 所有 10 個版本 

這是2009年唯一進入排行榜的論文。特色是：採用注射含氫氣生理鹽水作為給氫氣的手段，屬於在實驗技術上的革新，給臨床應用提供了更多遐想。

經典論文待續

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