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“氫水” 氫氣治療apoE基因缺陷動物的動脈硬化(當心假氫水破財又傷身)

 氫氣治療apoE基因缺陷動物的動脈硬化  0277086600 

 

已有 3238 次閱讀 2009-2-10 20:20 |個人分類:飲用氫氣水|系統分類:科研筆記|關鍵字:論文,氫氣,抗氧化

這個文章是讓動物從出生開始飲含氫水6個月,發現對動脈硬化具有非常理想的治療效果。

Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice


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Ikuroh Ohsawaab, Kiyomi Nishimakia, Kumi Yamagataa, Masahiro Ishikawaa and Shigeo OhtaaCorresponding Author Contact InformationE-mail The Corresponding Author

aDepartment of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan

bThe Center of Molecular Hydrogen Medicine, Institute of Development and Aging Sciences, Nippon Medical School, Kawasaki 211-8533, Japan


Received 16 October 2008. 

Available online 6 November 2008.

 

Abstract

Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H2) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat. Med. 13 (2007) 688–694]. Here, we investigated whether drinking H2-dissolved water at a saturated level (H2–water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE−/−), a model of the spontaneous development of atherosclerosis. ApoE−/− mice drank H2–water ad libitum from 2 to 6 month old throughout the whole period. Atherosclerotic lesions were significantly reduced by ad libitum drinking of H2–water (p = 0.0069) as judged by Oil-Red-O staining series of sections of aorta. The oxidative stress level of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H2-dissolved water has the potential to prevent arteriosclerosis.

Keywords: Antioxidant; ApoE; Arteriosclerosis; Atherogenesis; Dihydrogen; Lifestyle-related disease; Macrophage; Molecular hydrogen; Oxidative stress; Preventive medicine

Article Outline

Materials and methods

Results

Discussion

Acknowledgements

References

 

 

 


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本文引用地址:http://blog.sciencenet.cn/blog-41174-214197.html 

 

低氘氫水實驗室

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