氢分子医学的新启示：一些临床药物的奇怪作用
Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?
Yoshihiko Suzukia, Motoaki Sanoc, 
, 
, Kentaro Hayashidac, Ikuroh Ohsawaa, b, Shigeo Ohtaa and Keiichi Fukudac
The major side-effect of treatment with α -glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of α -glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H 2in the gastrointestinal tract. Acarbose, which is an α -glucosidase inhibitor, markedly increased H 2production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H 2acts as a unique antioxidant, and that when inhaled or taken orally as H 2-dissolved water it ameliorates ischaemia–reperfusion injury and atherosclerosis development.
Keywords: α -Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant
Corresponding author. Address: Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Fax: +81 3 5363 3875.
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