氫水還原健康-氫氣治療維生素C缺乏引起的神經損傷

30 4 月, 2010
作者: 低氘氫水實驗室
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這個研究採用基因缺陷動物模型，對這個模型不太熟悉。有研究發現這種動物在維生素C缺乏時，腦內超氧離子水平升高。看來是一個腦氧化損傷的模型。這個文章也有體外腦片的內容。不過好像不是直接效應，而是用了氫後造成的後續影響。因此說可影響超氧陰離子的說法不准確。最近我們在投稿時，有人根據這個文獻給我們提出：選擇性抗氧化的作用不能明確。有一些強詞奪理。

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice
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Yasunori Sato ^a^,^b^,¹, Shizuo Kajiyama ^c^,¹, Akiko Amano ^b, Yoshitaka Kondo ^b, Toru Sasaki ^d, Setsuko Handa ^b, Ryoya Takahashi ^a, Michiaki Fukui ^e, Goji Hasegawa ^e, Naoto Nakamura ^e, Hikohito Fujinawa ^f, Toyotaka Mori ^f, Mitsuhiro Ohta ^g, Hiroshi Obayashi ^h, Naoki Maruyama ^band Akihito Ishigami ^a^,^b^,^,

^aDepartment of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University, Chiba 274-8510, Japan

^bAging Regulation, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan

^cKajiyama Clinic, Kyoto 615-0035, Japan

^dResearch Team for Molecular Biomarker, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan

^eDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

^fI’rom Pharmaceutical Co., LTD., Tokyo 141-0032, Japan

^gDepartment of Medical Biochemistry, Kobe Pharmaceutical University, Kobe 658-8566, Japan

^hInstitute of Bio-Response Informatics, Kyoto 612-8016, Japan

Received 31 July 2008.

Available online 14 August 2008.

Abstract

Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen’s effect in the brain, we administered hydrogen-rich pure water (H ₂) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout ( KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant. These KO mice were divided into three groups; recipients of H ₂, VC, or pure water (H₂O), administered for 33 days. VC levels in H ₂and H ₂O groups were <6% of those in the VC group. Subsequently, superoxide formation during hypoxia-reoxygenation treatment of brain slices from these groups was estimated by a real-time biography imaging system, which models living brain tissues , with Lucigenin used as chemiluminescence probe for superoxide. A significant 27.2% less superoxide formed in the H ₂group subjected to ischemia–reperfusion than in the H ₂O group. Thus hydrogen-rich pure water acts as an anti-oxidant in the brain slices and prevents superoxide formation.

Keywords: Ascorbic acid; Chemiluminescence; Gluconolactonase; Hydrogen-rich pure water; Oxidative stress; ROS; Senescence marker protein-30; Superoxide; Vitamin C

Abbreviations: EDTA, ethylenediaminetetraacetic acid; GNL, gluconolactonase; HPLC, high-performance liquid chromatography; KO, knockout; ROS, reactive oxygen species; SMP30, senescence marker protein-30; SOD, superoxide dismutase; VC, vitamin C

Article Outline

Materials and methods
Results
Effect of hydrogen-rich pure water on body weight
Total vitamin C levels in the brain after ingestion of hydrogen-rich pure water
Superoxide formation during hypoxia-reoxygenation in a model of the living brain
Discussion
Acknowledgements
References

全文

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